Framework for Characterizing Longitudinal Antibody Response in Children After Plasmodium falciparum Infection

Human Plasmodium infection produces a robust adaptive immune response. Time courses for 104 children followed 42 days after initiation of falciparum chemotherapy were assayed antibody levels to the five isotypes human immunoglobulins (Ig) and 4 subclasses IgG 32 P. antigens encompassing all parasite stages infection. IgD IgE against these undetectable at 1:100 serum concentration, but other Ig consistently observed antigens. Five quantitative parameters developed directly compare response among antigens: C max , maximum level; Δ difference between level Day 0; t time in reach ; 1/2 signal half-life days; neg estimated number until complete loss signal. Classical patterns bloodborne pathogen seen with IgM showing early production highest isotypes. However, some unexpected trends such as IgA biphasic pattern many Variability dynamics acquisition was noted different able be compared both quantitatively statistically. This parametrization methodology allows direct comparison produced various following malaria infection, same could applied longitudinal serologic studies from or pathogens. Specifically seroepidemiological studies, reliable estimates regarding populations can better optimize modeling efforts serological outputs.